Benefits And Science

Senescent cells accumulate in aging gut tissue too. Here’s what mouse colitis and Parkinson’s-model research shows about fisetin, the gut lining, and the microbiome.

Osteoarthritis is, at its core, a disease of cartilage breakdown, and a growing body of research has identified senescent chondrocytes

Fisetin’s reputation rests almost entirely on one mechanism: senolysis, the selective clearance of senescent ‘zombie’ cells. But a separate and

Fisetin is under study as a senolytic compound that may clear senescent cells in the dermis. Here is what the current evidence actually shows.

Fisetin is studied as a senolytic targeting ‘zombie’ cells. Here’s an honest look at what mouse research shows—and what remains unknown in humans.

Fisetin is studied as a senolytic and senomorphic agent that may reduce SASP-driven inflammation. Here is what the current preclinical evidence actually shows.

A close look at the landmark 2018 EBioMedicine study on fisetin, senescent cells, and lifespan extension in mice—what it found and what it means for humans.

Fisetin is a plant flavonoid studied for metabolic effects including insulin resistance and diabetic complications. An honest look at the early evidence.

A plain-language look at AFFIRM-LITE, Mayo Clinic’s pilot trial testing fisetin as a senolytic in older adults with physical dysfunction and frailty.

Can the senolytic flavonoid fisetin shift your biological age? A careful look at DNA methylation clock research, honest findings, and real limitations.

Fisetin is a naturally occurring flavonol found in a surprisingly wide range of everyday fruits and vegetables, though it tends

Explore the evidence on fisetin’s cognitive benefits, including memory, learning, and neuroprotection. What animal studies show — and what remains unproven in h