Dosage And Safety

At 40 to 80 micromolar, fisetin breaks DNA in cancer cells. Here is what that means, and how far it sits above anything a supplement puts in your blood.

A triple-blind trial will give adults over 50 just 100 mg of fisetin a day for seven weeks. What it measures, why, and what it cannot tell you yet.

The first human pharmacokinetic study of fisetin measured what reaches plasma after a 1,000 mg dose. The answer reframes how to read every fisetin label.

Two papers, from 1996 and 2002, name fisetin as an inhibitor of thyroid enzymes. Neither is obscure, both are indexed

There’s no human safety data on fisetin during pregnancy or breastfeeding. Here’s what actually exists (an animal study, not a human one) and why the standard advice is unanimous.

Fisetin is being studied as a senolytic for cancer survivors, but the active trials give it only after chemo ends, not during. Here’s why timing and a real enzyme-inhibition interaction matter.

Curious whether fisetin is doing anything for you? Here’s how to structure a personal n=1 protocol honestly — including what one biohacker’s bloodwork actually found.

Fisetin is poorly water-soluble. Learn why pairing it with dietary fat may improve absorption, what timing research suggests, and who should be cautious.

A clear-eyed look at fisetin side effects, drug interactions, and the significant gaps in human safety data for this senolytic flavonoid.

What fisetin senolytic supplement users actually report, from digestive discomfort and fatigue to bioavailability-related dosing confusion.

An honest, evidence-based review of fisetin safety for older adults: the senolytic hypothesis, preclinical findings, drug interactions, and real evidence limits

Comparing fisetin capsules and powder on dose flexibility, cost, convenience, and absorption. An honest guide to choosing the right supplement form.