Author name: Maya Okonkwo

Fisetin calmed psoriasis-like and eczema-like skin inflammation in lab skin and mice, mostly applied to the skin. No patient trial exists. Here is the evidence.

Fisetin reduced artery plaque and lowered cholesterol in mice bred to develop atherosclerosis. No human trial has tested it. Here is what the studies show.

A double-blind trial gave fisetin to colorectal cancer patients during chemotherapy. Read carefully, it found less than it is usually cited as finding.

Most fisetin human research is small, short, and aimed at slow outcomes such as frailty or biological age. There is

Fisetin protects the brain in animal head injury models, and one study used a genetic knockout to prove the mechanism. Nearly all of it dosed before the injury or within 30 minutes of it, which is not how head injuries happen.

Fisetin shrinks infarct size in rodent stroke models with unusual consistency across labs. It is also one of the areas where the gap between an animal model and a real emergency is widest.

Fisetin improved fatty liver in mice across several models, but almost every study injected it rather than feeding it, and no human trial has tested it for liver disease. Here’s what that actually means.

Age-related macular degeneration (AMD) is the leading cause of vision loss in older adults in Western countries, and researchers increasingly

Osteoarthritis is, at its core, a disease of cartilage breakdown, and a growing body of research has identified senescent chondrocytes,